Suspension
Fenbendazole 10%
Broad-spectrum dewormer
Composition:
Contains per ml:
Fenbendazole 100 mg
Polysorbate 80, Simethicone emulsion 30 %, Benzyl alcohol (E1519) and Purified water.
Description:
Fenbendazole is a broad-spectrum anthelmintic for infections caused by micro-organisms susceptible to fenbendazole, e.g. Ostertagia spp., Trichostrongylus spp., Haemonchus spp., Bunostomum spp., Trichuris spp., Cooperia spp., Nematodirus spp., Oesopagostomum spp., Strongyloides spp. and Dictyocaulus viviparus and Dictyocaulus filaria. Fenbendazole also treats and controls the following roundworm infections: larger Strongylus (adult and larval stages of Strongylus vulgaris, adult and larval stages of Strongylus edentatus). Fenbendazole is also effective in treatment and control of encysted mucosal immature small Strongylus larvae and against encysted inhibited small Strongylus larvae in the mucosa. Adult and immature Oxyuris spp., Strongyloides spp. and Parascaris equorum. L5 and adult stadium of Ascaridia Galli and Heterakis Gallinarum.
The suspension particles are in the sub-micron size range.
Pharmacodynamic properties:
Fenbendazole is an anthelmintic belonging to the benzimidazole-carbamate group. It acts by interfering with the energy metabolism of the nematode.
Fenbendazole inhibits the polymerization of tubulin to microtubules. This interferes with essential structural and functional properties of the cells of helminths, such as formation of the cytoskeleton, formation of the mitotic spindle and the uptake and intracellular transport of nutrients and metabolic products. Fenbendazole is effective and has a dose dependent effect on adult and immature stages. Fenbendazole has an ovicidal effect on nematode eggs.
Pharmacokinetic properties:
After oral administration fenbendazole is only partially absorbed. Following absorption, fenbendazole is rapidly metabolized in the liver mainly to its sulphoxide (oxfendazole) and further to its sulphone (oxfendazole sulphone). In pigs oxfendazole is the main component detected in plasma, accounting for about 2/3 of the total AUC (i.e. the sum of the AUC for fenbendazole, oxfendazole and oxfendazole sulphone). In chickens oxfendazole sulfone is the main component detected in plasma, accounting for about 3/4 of the total AUC (ie the sum of the AUC for fenbendazole, oxfendazole and oxfendazole sulphone). Fenbendazole and its metabolites are distributed throughout the body, reaching highest concentrations in the liver. The elimination of fenbendazole and its metabolites occurs primarily via the faces and to a small extent in the urine (pigs).
Indications:
FORCURE Oral suspension is indicated for the treatment of mature and immature stomach, intestinal and lung worms and eggs in poultry, cattle, horses, sheep, goats, pigs and pets.
Prophylaxis and treatment of gastrointestinal and respiratory worm infections and cestodes in calves, cattle, goats, sheep and swine such as: Gastrointestinal roundworms: Bunostomum, Cooperia, Haemonchus, Nematodirus, Oesophagostomum, Ostertagia, Strongyloides, Trichuris and Trichostrongylus spp., Lung worms: Dictyocaulus viviparous and Tapeworms: Monieza spp.
Dosage and Administration:
For oral administration via drinking water.
Broilers:
Age in days ml of product per 1,000 liters of drinking water
0 – 7 25
8 – 14 31
15 – 21 36
22 – 28 42
29 – 35 49
36 – 42 56
This is equivalent to 1 mg per kg bodyweight, Treat during 5 consecutive days.
- Layers and breeders: 30 ml per 1,000 liters of drinking water during 5 consecutive days. This is equivalent to 1 mg per kg bodyweight.
- Cattle, sheep, goats: 5 ml per 100 kg bodyweight.
- Pigs: 5 ml per 100 kg bodyweight during 3 consecutive days.
- Horses: 7.5 ml per 100 kg bodyweight.
- Dogs, cats: 1 ml per 10 kg body weight (once)
Medicated drinking water should be used within 24 hours. One-time treatment, repeat in case of re-infections after 3 – 4 weeks.
Under conditions of continued exposure to parasites, re treatment may be needed after 4 to 6 weeks.
Withdrawal Time:
Meat: Ruminants, pigs: 14 days
Horses: 20 days
Poultry: 6 days
Milk: 4 days
Eggs: 0 days
RESIDUE WARNINGS: Cattle must not be slaughtered within 8 days following treatment. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Goats must not be slaughtered for food within 6 days following treatment. Because a withdrawal time in milk has not been established, do not use in lactating goats. For dairy cattle, there is no milk withdrawal period
Contra-indications:
Do not use in case of Capillaria spp infestations.
Special warnings for each target species
Parasitic resistance to any particular class of anthelmintic may develop following frequent repeated use of an anthelmintic of that class.
Special precautions for use:
In the absence of available data, treatment of chickens less than 3 weeks of age should be based on a benefit/risk assessment by the responsible veterinarian.
The efficacy of the veterinary medicinal product at the recommended dosage is not sufficient for the treatment of infestations with Capillaria spp. The absence of Capillaria spp infestation should be confirmed prior to use of the product. In case of Capillaria infestation another appropriate anthelmintic veterinary medicinal product should be used. Use of the product deviating from the instructions in the SPC may increase the risk of development of resistance.
Operator warnings:
This veterinary medicinal product may be toxic to humans after ingestion. Embryotoxic effects cannot be excluded. This product may cause hypersensitivity reactions.
Avoid contact with skin, eye and mucous membranes. Pregnant women must take extra precautions when handling this veterinary medicinal product.
Wear protective gloves at all times while handling the veterinary medicinal product and cleaning the measuring device. Wash hands after use.
In case of skin and/or eye contact, immediately rinse with plenty of water. Remove contaminated clothes after spillage.
Other precautions:
The veterinary medicinal product should not be allowed to enter surface waters as it has harmful effects on aquatic organisms.
Adverse reactions:
None known.
Use during pregnancy, lactation or lay
Can be used during pregnancy, lactation or lay.
Compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Side Effects:
With proper use and dosage, side effects are usually not observed.
Target species:
Cattle, Horses, sheep, goats, Poultry, Pigs, and pets.
Shelf life:
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: 6 months.
Shelf life of the medicated drinking water: 24 hours.
Special precautions for storage:
Store at or below 25°C (77°F). Protect from freezing.
Store in closed packing.
Keep medicine away from children.
Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.
Pack size: 1 liter.
For Use in Animals Only.
Shake well before use
